RIDD activities are differentially regulated functions of the UPR transducer IRE1.
- Brand – RIDD
- Categories – Medicine
RIDD is a conserved ancestral mechanism regulating proteostasis in different eukaryotic phyla.
RIDD has a basal activity that is required to maintain ER homeostasis.
XBP1 splicing and RIDD produce opposite effects on cell fate in cells subjected to ER stress.
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